Liberia’s Ebola vaccine trial begins

first_img Tweet HealthLifestyle Liberia’s Ebola vaccine trial begins by: BBC News – February 2, 2015 Sharing is caring! Share Sharecenter_img More than 3,600 people have died from Ebola in LiberiaThe first large-scale trials of two experimental vaccines against Ebola have begun in Liberia.The potentially preventative medicines were taken under strict security to a secret location in the West African country.Scientists aim to immunise 30,000 volunteers, including front-line health workers.More than 8,500 people have died in the Ebola outbreak, the vast majority in Guinea, Liberia and Sierra Leone.The total number of reported cases is more than 21,000. In Liberia alone, more than 3,600 people have died from the disease.The trial beginning on Monday involves injecting a small amount of a strain of the Ebola virus into 12 volunteers in order to trick the body into producing an immune response. More volunteers will be immunised as the trial progresses.However, it is not yet clear whether the trial vaccines will offer protection against the disease.The vaccine is still experimental and it is not clear whether it will definitely provide protection against EbolaVaccines train the immune systems of healthy people to fight off any future infection.They often contain a live but weakened version of the virus.Correspondents say the trials are testing two vaccines created by two different drug companies who are hoping that the international community will eventually seek to stockpile large quantities of a working vaccine.The first man to receive the vaccine was a middle-aged Liberian, the BBC’s Mark Doyle reports from the Liberian capital Monrovia.Asked how he felt after his jab, he smiled and gave me the thumbs-up, our correspondent says.The senior Liberian scientist involved in the trials, Stephen Kennedy, told the BBC the volunteers were safe.“There is no danger because the piece of the Zaire strain that has been put into the vaccine is a weak strain and it cannot and will not cause Ebola, so it is impossible that any one of the volunteers will contract Ebola from the vaccine,” Mr Kennedy said.The scientists are well aware of how important the support of local people will be if this trial is to work, our correspondent says.Community nurses are being trained in how to monitor volunteers in the months after they have their injections.Parts of the largest Ebola treatment centre in the world, on the edge of Monrovia, are being knocked down, our correspondent says.The number of Ebola cases in Liberia has been steadily decreasing, with only five confirmed cases in recent months.According to the World Health Organization, the epidemic has entered a “second phase” with the focus shifting to ending the epidemic.Survival rate for the current outbreak is around 40%.The scale of the outbreak has sparked a race to find a cure for the disease, with many vaccines and drugs being fast-tracked for human testing.Safety trials for potential vaccines have taken place in the UK and in Switzerland and two potential drugs have been tested at Ebola treatment facilities run by medical charity Medecins Sans Frontieres.Doctors have also been trialling serum therapy, a treatment made from the blood of Ebola survivors who have recovered. Share 115 Views   no discussionslast_img read more

Sherwood demands display from Chiriches

first_img Press Association Tottenham manager Tim Sherwood says Vlad Chiriches must produce a performance against Manchester City strong enough to shrug off the gossip surrounding a video which apparently showed him drunk in Bucharest last weekend. The ex-Rovers captain said they almost knew they would win any time opponents parked 10 men behind the ball. Exhorting his side into an attacking mindset, he said: “You’ve got to have your own threats, you’ve got to push them back. “There are no more attacking full-backs in the league than the two in that Man City side. “At Blackburn we could definitely sense fear, we could see teams coming when they put 10 behind the ball: they were just waiting to get beaten. “I’m not a believer in that, you can have a lot of people behind the ball and still get hammered.” Sherwood hailed Pellegrini for debunking the current vogue myth that no side can win silverware without two holding midfielders. While the Spurs head coach will shift his systems to best suit resources, he still considers 4-4-2 to be one of the most deadly formations out there. “It’s never out of fashion in my eyes: there are just times to play 4-4-2 and times not to,” said Sherwood. “I always maintain players win games not formations. “I never used to play with a holding midfielder, just two who can do everything, adapt and be clever in how they play with each other. “And that’s what they’ve got with Fernandinho and Toure. “Pellegrini’s making a mockery of that boring, old English 4-4-2 isn’t he? “Everyone says it’s old hat, well they are running away with the league playing 4-4-2 and Man United did for years.” Injuries and the fallout from Villas-Boas’ departure have forced Sherwood into making a number of changes. Striker Emmanuel Adebayor’s form following his Villas-Boas inflicted exile might be the most striking, but Sherwood has laid credit for Spurs’ resurgence at the feet of his players. “The boys that are in the frame at the moment weren’t even playing,” he said. “It has been a manic time, yeah, it’s been needs-must for us a little bit, because a lot of the other boys have been injured. “I’ve been dealt the cards and I’m pleased with the outcome. “The team has improved itself, I think it’s just given some belief and confidence into the players. “It’s not looking from where they were to where they are now; it’s just putting my stamp on it. “They are on board and results have been good.” “I did see that, yes,” said a bemused but unfazed Sherwood. “I’ve fallen over in the snow before and all. “He’s had a weekend off and he’s got to play well on Wednesday. “No (he will not face a fine), he wasn’t breaking any rules. “For his own sake you wish he didn’t (do it). “He was unsteady on his legs by the looks of it; it must have been windy over there.” Manchester City ravaged Spurs 6-0 at the Etihad Stadium in November, a seismic result on the way to Andre Villas-Boas’ exit. Sherwood will still tell Spurs to forget that result and go on the attack against Manuel Pellegrini’s free-scoring City outfit on Wednesday. When Blackburn won the league with Alan Shearer and Chris Sutton up front, Sherwood anchored the midfield alongside David Batty. Admitting he had seen the video, posted on the internet on Monday, Sherwood confirmed Spurs will not fine the Romanian defender. Chiriches is in line to face City in Spurs’ White Hart Lane Barclays Premier League clash on Wednesday, with Sherwood challenging him to brush off his weekend antics. last_img read more

Alexander: Kobe’s death a gut punch to L.A. fans

first_imgMy personal interaction began before all of that, with a phone call to the house.Bryant, who had just turned 18 and was still a month away from his first NBA training camp, fractured his wrist in a pick-up game at Venice Beach in early September of 1996. When he returned a phone call for a story about that injury and the fact he would miss the start of training camp, our daughter – 19 at the time – picked up the phone. She still marvels at the idea she talked to Kobe Bryant before he was somebody.What he said in that subsequent conversation probably was a glimpse of what we were going to get for the next two decades: “It happened, and now it’s time to move on. I’m still working out, still keeping myself in shape. I’m just minus a left wrist right now.”He was supremely confident from the beginning. Sometimes it backfired, as in the case of that series-deciding game in Utah. He took the last shot in regulation and missed. Then, with the Lakers down three at the end of overtime, Bryant attempted two deep 3-pointers from the left wing, missed both, and after the Lakers had lost and been eliminated said this:“If we play this game again, I want the ball again. Tonight I just didn’t come through, but there will be plenty more chances down the line.”The Lakers’ Shaquille O’Neal and Kobe Bryant share a laugh during the final minutes of the the Lakers’ 117-103 victory over the New York Knick at the Staples Center Sunday March 10, 2002. (Photo by Kevin Sullivan, Orange County Register/SCNG)There were. Bryant’s confidence never wavered, and neither did his discipline or work ethic, combined with a drive to be great. Thus, the three-peat of 2000-01-02 with Shaq. Or the 81-point game against Toronto in January, 2006. Or, in another way, the days in the summer of 2007 when, distraught that the Lakers weren’t making enough moves to return to championship level, he asked for a trade and declared that he’d just as soon play on Pluto.That worked, too. The Lakers didn’t dare trade him, but eventually, they acquired Pau Gasol as his wingman and won championships in 2009 against Orlando and 2010 against the Celtics. That last title gave us the iconic image of Bryant, standing on the Staples Center scorer’s table, the game ball in his left hand as the confetti fell and the fans rejoiced.“Nobody works harder,” Lakers trainer Gary Vitti told us in 2008, the day Bryant received his only league MVP trophy. “Nobody’s tougher. Nobody’s more talented, and nobody’s more competitive. When you’ve got those four things, if you can’t win an MVP, something’s wrong.”That might have had something to do with his occasional friction with certain teammates. He couldn’t understand why they didn’t work as hard as he did. And when Bryant ripped his Achilles tendon in April of 2013 against the Warriors and still dragged himself to the line to take his two free throws before going to the locker room … that, too, was iconic Kobe.All of those memories will be revisited in the days to come. The Lakers are next scheduled to play Tuesday at home against the Clippers. Imagine what that will be like.PreviousFans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG) SoundThe gallery will resume insecondsFan gather around make shift memorials as they mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of Kobe Bryant fans converge outside Staples Center to honor the former Lakers player who died Sunday, January 26, 2020 in a helicopter crash near Calabasas, Calif. He was 41. (Photo by Mindy Schauer, Orange County Register/SCNG)Fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Make shift memorials as fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Fans bring flowers as they mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Make shift memorials as fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Pete Reyna of Paramourn carries a giant picture of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers as fans mourn the loss of Kobe Bryant in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Fans mourn the loss of Kobe Bryant with make shift memorials in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Thousands of fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)NextShow Caption1 of 16Thousands of fans mourn the loss of Kobe Bryant in front of La Live across from Staples Center, home of the Los Angeles Lakers in Los Angeles on Sunday, January 26, 2020. Kobe Bryant and 8 others died in an helicopter crash in Calabasas. (Photo by Keith Birmingham, Pasadena Star-News/SCNG)Expand AD Quality Auto 360p 720p 1080p Top articles1/5READ MOREUCLA alum Kenny Clark signs four-year contract extension with PackersIt’s because we watched Bryant come in as an 18-year-old prodigy, evolve into a 25-year-old star – immensely talented and just as immensely headstrong – and then into the mid-30s veteran with his intense competitive thirst, and finally into the elder statesman gracious enough and respectful enough to welcome LeBron James into the Lakers’ fold, even when large portions of the team’s fan base resisted embracing James because they felt it downgraded Kobe. Related linksStaples Center, Kobe Bryant’s ‘house,’ becomes a place of mourningKobe Bryant, one of the greatest Lakers ever, dies at 41Map: Kobe Bryant helicopter route from takeoff to deadly crashKobe Bryant and 13-year-old daughter Gianna among 9 killed in helicopter crash in CalabasasLeBron James passes Kobe Bryant for 3rd place on NBA’s career scoring list The news was a gut punch Sunday morning. Kobe Bryant, gone?No. It can’t be.But it was. The helicopter crash that killed nine including Bryant, 41, and his daughter Gianna, 13, en route to her basketball game Sunday morning was grieved nationally, and internationally, at all levels of basketball.It will be felt most intensely in Los Angeles. It already is. People felt they had to go to Staples Center and to L.A. Live Sunday afternoon, to grieve and to share their emotions.center_img It’s a cruel, cruel coincidence that Bryant was back in the news the past few days, as James prepared to pass Bryant as the No. 3 scorer in NBA history. Saturday night, when James surpassed Bryant’s 33,643 career points in the Lakers’ loss in Philadelphia, he reminisced about Bryant – about seeking him out when James the high school superstar considered following Bryant’s direct path to the pros, and about later playing alongside Bryant on U.S. Olympic teams. The timing was haunting.Bryant’s legacy was complicated. The events of 2003 in Eagle, Colo., color some people’s memories of Bryant. Others remember him primarily for that competitive stubbornness that made his early-2000s partnership with Shaquille O’Neal such a devastating combination but also made it ultimately impossible to sustain.But in L.A. he was beloved, unconditionally, largely because he was a Laker for life.Laker fans endured the growing pains – the airballs in overtime at Utah in the 1997 playoffs, the friction with then-coach Del Harris those first couple of years over whether he was ready to start, and the disagreements about whose ball it was, his or Shaq’s. And they celebrated the triumphs: Five championships, an MVP award, two Finals MVPs, two scoring titles. Even an Academy Award, for crying out loud, in a post-basketball career producing kids’ stories and becoming a passionate advocate for girls’ and women’s basketball. Newsroom GuidelinesNews TipsContact UsReport an Errorlast_img read more